Otto Loewi

From the Workshop of Discoveries From the Workshop of Discoveries

Otto Loewi & Neurochemical Phenomena.

*Professor of Medicine, T.N. Medical College (Retd.), Hon. Physician, Bhatia Hospital, Mumbai; **Consultant Internal Medicine, Kokilaben Dhirubhai Ambani Hospital, Mumbai O Loewi (1873 1961) studied medicine at the University of Strasbourg and obtained his medical degree in 1896. Thereafter he worked in London under Starling. In 1905, he went to Austria and held professorial positions at the Un...

Otto Loewi: Ein Lebensbild in Dokumenten

Otto Loewi was born in Frankfurt in 1873, became professor of pharmacology in Graz in 1909 and laid the foundation of the theory of neurochemical transmission in 1920. For this he shared a Nobel prize with Dale in 1936, and in 1938, for being Jewish, he was briefly imprisoned and then expelled from Australia. He then emigrated to the United States where he spent the rest of his life. Loewi wrot...

Autopharmacology- a Review

INTRODUCTION Historically, the first approach to the concept of autopharmacology began with British physiologist and pharmacologist Henry Dale in the 1910s, discovered the role of acetylcholine in synaptic transmission, and later proved by Austrian physiologist Otto Loewi, to be the neurotransmitter involved in the proximal synapses of the autonomic nervous system (initially named Vagusstoff by...

Autonomic modulation preceding the onset of atrial fibrillation.

Autonomic influences on the heart have been recognized for many centuries. It was not until 1921, however, that a German physiologist named Otto Loewi stimulated a frog’s vagus nerve, collected the released substance, and applied it to a second, different frog heart to demonstrate its effects. For his discovery of this “vagusstuff” (subsequently shown to be acetylcholine), Loewi (1) shared the ...